This important study builds on previous work from the same authors to present a conceptually distinct workflow for cryo-EM reconstruction that uses 2D template matching to enable high-resolution ...

PPA constraints need to be paired with real workloads, but they also need to be flexible to account for future changes.

In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

Background Patients with severe aortic stenosis (AS) are at high risk of mortality, regardless of symptom status. Despite ...

Background Annually, 4% of the global population undergoes non-cardiac surgery, with 30% of those patients having at least ...