Genetic prediction of common diseases is based on testing multiple genetic variants with weak effect sizes. Standard logistic regression and Cox Proportional Hazard models that assess the combined ...

Reduced rank approximation of matrices by Householder-Young methods is shown to be equivalent to fitting of a bilinear (multiplicative) model and to projection onto an optimally chosen subspace. The ...

Epistasis may play an important role in evolution and speciation. Under multiplicative interactions between different loci, an analytical model is proposed to estimate genetic parameters at the ...