纵观整项研究，我们不仅看到了FOCAS这一强大工具的威力，更看到了它所揭示的生物学复杂性。过去针对m6A的抗癌策略往往类似于“地毯式轰炸”（如全局抑制METTL3或FTO），虽然有效，但伴随着破坏管家功能的风险。

Traditionally, cancer diagnosis and prognosis rely heavily on histopathological examination, where tissue morphology is evaluated under the microscope. However, the molecular ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Early detection of declining forest health is critical for the timely intervention and treatment of droughted and diseased ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

12月31日，北京大学以“FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of ...

PCR-based techniques have transformed how scientists analyze transcripts’ translational applications in cancer and ...

Inducible promoters provide remarkable utility when sustained transgene expression compromises plant development or agronomic performance.

Scientists studying Alzheimer’s in African Americans have uncovered a striking genetic clue that may cut across racial lines.

Genetics is the study of genes and how they influence characteristics and health. Through a variety of technological methods, environmental factors, and lifestyle choices, it is possible to alter some ...