来自挪威奥斯陆大学等机构的科学家们通过研究揭示了DNA碱基切除修复（BER，base excision repair）通路在帕金森疾病发病机制中所扮演的新角色。相关研究结果阐明了BER失衡在帕金森疾病发病机制的有害影响效应背后的新型分子机制。 2021年9月20日 讯 /生物谷BIOON ...

Nucleotide excision repair (NER) is a major conserved DNA repair pathway, which repairs various types of damage in the genome, such as those induced by ultraviolet light and environmental agents.

The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...

The parametric estimation procedure to predict long-term efficacy on survival from publication data of clinical trials for metastatic colorectal cancer (mCRC). This is an ASCO Meeting Abstract from ...

A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...

The excision repair cross-complementation group 1 (ERCC1) protein is a potential prognostic biomarker of the efficacy of cisplatin-based chemotherapy in non–small-cell lung cancer (NSCLC). Although ...

Efficacy of novel proteasome inhibitory platinum complex against osteosarcoma. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does not include a full text ...

Damage to your DNA is unavoidable. Every day our cells are bombarded by gene-splitting UV radiation or chemical carcinogens. Regular water inside our bodies can cause DNA damage. DNA damage is as ...

Maintaining the stability of the genome is essential for all organisms, and it is not surprising that damage to DNA has been proposed as an explanation for multiple chronic diseases. 1–5 Conserving a ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...