导读人类胚胎常在受精后至着床前的关键发育节点停滞，导致不孕和妊娠丢失等临床问题。受精卵形成后，合子基因组激活(ZGA)是胚胎发育经历的第一个关键节点。此时，胚胎逐步脱离对母体RNA和蛋白质的依赖，向合子基因自主表达模式过渡。ZGA异常是导致人类早期胚 ...

New findings offer insight into why some embryos fail to develop past zygotic genome activation (ZGA), pointing to an unexpected root of human infertility. A critical point in early development is ...

A stretch of viral DNA in the mouse genome gives cells in early-stage embryos the potential to become almost any cell type in ...

A new "atlas" of early embryonic development in mammals suggests that the process is highly chaotic — but there is some method to the madness. When you purchase through links on our site, we may earn ...

Hierarchical communication between cells with distinct positional memories orchestrates the regeneration of missing limb structures in axolotls.

New findings offer insight into why some embryos fail to develop past zygotic genome activation (ZGA), pointing to an unexpected root of human ...

In the earliest hours after fertilization, an embryo takes its first steps toward becoming a living organism by shedding maternal control and activating its own genetic program. This critical process, ...

Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers ...

Over half of our genomes consists of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the "dark side" of the ...

A research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus. “They are not identical,” said Magdalena Zernicka-Goetz, a ...